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KMID : 0356620070220050344
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Journal of Korean Society of Endocrinology
2007 Volume.22 No. 5 p.344 ~ p.352
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A Case of Parathyroid Carcinoma Underwent Radiation Therapy on the Metastatic Bone Lesions
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Lee Jun-Ho
Kim Young-Min
Hwang Dae-Seong
Hwang Young-Tae
Eum Jun-Bum
Seo Jung-Min
Choi Dae-Hwa
Kang Byeong-Seong
Noh Young-Ju
NamGoong Il-Seong
Kim Young-Il
Kim Eun-Sook
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Abstract
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Parathyroid carcinoma is a rare malignancy that is responsible for only 0.5 to 4% of all cases of primary hyperparathyroidism. Surgery is the only curative treatment. We report a case of a 46-year-old woman referred for a severe osteoporosis with frequent bone fracture associated with hypercalcemia. Initially, though she had multiple osteolytic lesions, we thought that the lesions were brown tumors resulting from hyperparathyroidism. The patient underwent surgery and was diagnosed with parathyroid carcinoma. After surgery, her intact PTH level normalized for brief period of time, but it was again elevated at 6 weeks after surgery. We suggest that the multiple osteolytic lesions were metastases because there was no evidence of local recurrence of parathyroid carcinoma, and the lesions looked like metastases on CT and PET-CT. The patient was treated with radiation therapy on the lumbar vertebra, one a site of the metastatic lesions. After radiotherapy, her serum intact PTH was decreased.
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KEYWORD
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Multiple bone metastases, Parathyroid carcinoma, Radiation therapy
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